Check out this awesome half hour conversation with Facebook founder Mark Zuckerberg. He talks about building facebook, strategy and leadership advice. I love this great quote about how to build a competitive, fast-learning company (starts a minute 10 mark).
The key is building a company which is focused on learning as quickly as possible. Companies are learning organisms. In a lot of ways building company is like following the scientific method. You try a bunch of different hypothesis and if you set up the experiments well then you learn what to do.